Abstract
Glyceollins (I, II and III) are metabolites of the well‐studied isoflavone dadzein, and they appear to have different bioactivity from the isoflavones. The purpose of this study was to evaluate the effect of glyceollin‐enriched soybean on adipogenesis. Biosynthesis of glyceollins were induced in soybean cotyledons by inoculating with Aspergillus sojae. Cell proliferation and differentiation were determined by MTT assay and Oil Red O staining, respectively. Proliferation of 3T3‐L1 preadipocyte was promoted in a dose dependent manner by extracts of soy noninoculated‐ or inoculated with the fungus. Inoculated soybean extract inhibited differentiation of preadipocyte into adipocyte at the concentration of 500 ug/ml or higher. To confirm whether adipocyte differentiation by soy extract is due to glyceollins, the effect of purified glyceollins on lipid metabolism including the expression of PPAR‐gamma, PPAR‐alpha, and FAS has been evaluated.
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