Abstract
AbstractTri‐ and tetrasubstitutedortho‐bromobiaryls have been synthesized in good‐to‐excellent yields by aryne cross‐coupling reactions starting from 1,3‐dimethoxybenzene and functionalized 1,2‐dibromobenzenes. This study outlines the influence of the 1,2‐dibromobenzene precursor as well as the reaction temperature on the outcome of the aryl–aryl bond formation and indicates, in the case of dissymmetrical benzyne precursors, how structural parameters (electronic effects, steric hindrance, temperature, etc.) control the regioselectivity of the aryne cross‐coupling reactions.
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