Abstract
The high affinity binding of [ 3H]imipramine to membranes was compared in 7 brain regions from two psychogenetically selected rat lines (RHA/Verh, RLA/Verh). A significantly higher binding in RHA/Verh rats, as compared to RLA/Verh rats, was found in cortex and striatum. All other regions, except hypothalamus, showed a trend in the same direction (RHA/Verh > RLA/Verh). In the hypothalamus, however, [ 3H]imipramine binding for RLA/Verh rats significantly exceeded that found in RHA/Verh animals.
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