Abstract
BackgroundLow cardiorespiratory fitness (CRF), high body mass index, and excess visceral adiposity are each associated with impairment in left ventricular (LV) peak circumferential strain (Ecc), an intermediate phenotype that precedes the development of clinical heart failure (HF). However, the association of regional fat distribution and CRF with Ecc independent of each other and other potential confounders is not known.MethodsParticipants from the Dallas Heart Study Phase 2 who underwent dual energy X-ray absorptiometry assessment of regional fat distribution, CRF assessment by submaximal treadmill test, and Ecc quantification by tissue-tagged cardiovascular magnetic resonance were included in the analysis. The cross-sectional associations of measures of regional adiposity, namely visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and lower-body fat (LBF) with Ecc after adjustment for CRF and other potential confounders (independent variables) were assessed using multivariable linear regression analysis.ResultsThe study included 1089 participants (55% female, 39% black). In the unadjusted analysis, higher VAT was associated with greater impairment in Ecc. After adjustment for baseline risk factors, CRF, parameters of LV structure and function, and other fat depots such as SAT and LBF, higher VAT remained associated with greater impairment in Ecc (β: 0.19, P = 0.002). SAT and LBF were not significantly associated with Ecc, however, CRF remained associated with Ecc in the fully adjusted model including all fat depots (β: − 0.15, P < 0.001).ConclusionsVAT and CRF are each independently associated with impairment in Ecc, suggesting that higher VAT burden and low CRF mediate pathological cardiac remodeling through distinct mechanisms.
Highlights
Excess adiposity, as measured by body mass index (BMI), is associated with impaired myocardial function and higher risk of heart failure (HF) [1,2,3,4,5,6]
Kondamudi et al J Cardiovasc Magn Reson (2021) 23:78 (EDV) [5, 9], while cardiorespiratory fitness (CRF) has been associated with higher left ventricular (LV) filling pressures and diastolic dysfunction [10, 11]
We examined the associations between specific adipose tissue depots and Peak systolic circumferential strain (Ecc) while adjusting for cardiovascular disease (CVD) risk factors, CRF, and LV parameters in a multi-ethnic, population-based cohort without known CVD
Summary
As measured by body mass index (BMI), is associated with impaired myocardial function and higher risk of heart failure (HF) [1,2,3,4,5,6]. (EDV) [5, 9], while CRF has been associated with higher LV filling pressures and diastolic dysfunction [10, 11] These cardiac remodeling patterns may reflect intermediate phenotypes in the progression from at-risk to clinical HF [12, 13]. We hypothesized that higher amounts of VAT would be independently associated with greater subclinical impairment in LV contractility measured by Ecc. Low cardiorespiratory fitness (CRF), high body mass index, and excess visceral adiposity are each associated with impairment in left ventricular (LV) peak circumferential strain (Ecc), an intermediate phenotype that precedes the development of clinical heart failure (HF). The association of regional fat distribution and CRF with Ecc independent of each other and other potential confounders is not known
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
