Abstract
The reductive coupling of alkynes with aldehydes is a common method for preparing allylic alcohols. When unsymmetrical alkynes are used two regioisomeric products can be formed. Regiocontrol is possible with a strong steric or electronic bias in the alkyne. The authors have developed catalyst systems which are exceptionally sensitive to steric differences in unsymmetrical alkynes, allowing either regioisomeric trisubstituted alkene to be synthesized.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
