Abstract

Guided tissue regeneration and enamel matrix proteins are two regenerative techniques with promising clinical and histological results with regard to periodontal regeneration. AimThis literature review aims to compare the effectiveness of these two techniques when applied in the treatment of bone defects and to evaluate a possible benefit in using them together. Material and methodsMeta-analysis and randomized clinical trials for the treatment of bone defects in humans which compare the two treatment modalities in question or the combination of both. ResultsThis review includes five meta-analysis and three randomized clinical trials. ConclusionsWithin the limitations imposed by the type of review undertaken, we can conclude that both are effective in the treatment of bone defects and the combination of the two techniques does not seem to offer significant advantages in improving clinical outcomes when compared with the use of these treatments alone.

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