Abstract
Reports have appeared in the literature describing the refractory period in peripheral nerves, and its clinical usefulness is already established. There are however few such investigations in the central nervous system. The D-wave in motor evoked potentials (MEPs) and the N1-wave in spinal cord evoked potentials (SCEPs) have been reported as non-synaptic potentials in previous studies. Accordingly a refractory period as in peripheral nerves may be suggested in MEPs and SCEPs. Both potentials are important in the diagnosis of pyramidal tract damage. The aim of the present study was to demonstrate the existence of the refractory period in MEPs and SCEPs, and to determine its physiological characteristics compared with peripheral nerve in an animal study. Additionally, in an intracerebral haemorrhage model we tried to demonstrate the possibility of the application of the refractory period in MEPs as an index of pyramidal dysfunction.
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