Abstract
BackgroundWe aimed to develop the age- and sex-specific reference values for lipid profile of Iranian pediatric population.MethodsFasting lipid profiles of 3843 participants, aged 7 to 18 years, were extracted from a surveillance survey on Iranian children and adolescents living in 30 provinces across the country.ResultsThe mean (SD) age of participants was 12.3(3.1) years, and 52.3% of them were boys. Significant differences were observed between genders comparing the levels of triglyceride (TG) (P = 0.04), total cholesterol (TC) (P = 0.02), low-density lipoprotein- cholesterol (LDL-C) (P = 0.01), and non-high-density lipoprotein cholesterol (non-HDL-C) (P = 0.03). In both genders, TG levels increased with age in the 75th and higher percentiles. Among boys, TC showed a decreasing trend at all percentiles and all age groups. In girls, TC levels increased with age at all percentiles except for the 75th and 90th percentiles. Among boys, the levels of LDL-C and HDL-C decreased with age in all percentiles. However, LDL-C and HDL-C concentrations increased up to the 50th percentile in girls and then decreased with age. The non-HDL-C level decreased in the 50th and higher percentiles among boys and in the 90th and 95th percentiles among girls. The TG/HDL-C ratio increased with age at all percentiles in boys. In girls, TG/HDL-C ratio increased with age in the 50th and higher percentiles.ConclusionsBased on the observed differences, it seems necessary to determine age- and sex-specific cut-off values for lipid parameters of children and adolescents in different populations.
Highlights
We aimed to develop the age- and sex-specific reference values for lipid profile of Iranian pediatric population
The levels of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) decreased with age in all percentiles
The TG/ HDL-C ratio increased with age at all percentiles in boys
Summary
We aimed to develop the age- and sex-specific reference values for lipid profile of Iranian pediatric population. Dyslipidemia is one of the common problems in children and adolescents This condition is defined as disorders of triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Dyslipidemia can be developed in childhood and might lead to atherosclerotic lesions in adulthood [2] such as increased intima-media thickness [3]. Genetic form of hypercholesterolemia or familial hypercholesterolemia (FH) is an important issue in children as it can increase risk of CVDs later in life [4]. This disorder has two forms characterized by very high levels of LDL-C. Homozygous form of FH is rare, but it is associated with extremely high risk of
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