Abstract
Objective: Reference intervals are an essential part of laboratory medicine. Current study was planned to evaluate renal parameters in the healthy defined group of individuals which would serve as reference values of renal parameters for the North Indian population from Rajasthan.Design & Methods: Present study was conducted on 2021 apparently healthy individuals of North Indian origin ranging in age from 15-60 years, were selected randomly using defined criteria. Fasting samples were analyzed for Urea, Creatinine, Uric Acid, Sodium, Potassium and Chloride. Data were analyzed for middle 95 percentile (2.5th-97.5th percentile), median and 95% confidence interval using SPSS software package version 10.0.Result: RI for Urea, Creatinine and uric acid were lower in female (16-42mg/dl, 0.6-1.2mg/dl, 2.4-6.8mg/dl) as compared to male (17.00-44.35mg/dl, 0.7-1.5mg/dl, 2.8-7.2mg/dl). There was a progressive increase in urea, uric acid and Creatinine with increase in age. Though no appreciable differences could be observed in respect to most of renal parameters in rural versus urban, a wider range for uric acid was observed in urban population (2.50-7.20mg/dl). Except for Na+, K+ and Cl-, rest of parameters i.e. urea, creatinine, uric acid were higher range in obese as compared to non obese (17-45 Vs 17-44, 0.66-1.5 Vs 0.60-1.40, 2.5-7.4 Vs 2.5-7.0). Uric acid level was also found to be higher in non vegetarian population (2.6-7.5mg/dl).Conclusion: Findings of this study provide sex, age, BMI, habitat and diet specific renal function reference values to be used for North Indian population.
Highlights
Reference intervals serve as the basis of laboratory testing and aid the physician in differentiating between the healthy and diseased patient
The significantly higher values of the reference ranges for urea, creatinine and uric acid in males compared to females indicates sex differences in these kidney function test parameters
Among various biochemical parameters examined in relation to renal functions except urea, uric acid and Creatinine rest all parameters remained unchanged with advancing age
Summary
Reference intervals serve as the basis of laboratory testing and aid the physician in differentiating between the healthy and diseased patient. The population-based reference interval is the most widely used tool for interpretation of individual patient laboratory test results [1]. Reference values are used in interpreting results of laboratory measurements, clinical trials screening and as the basis of safety monitoring for trial participants [2]. These reference values are used to assess health in humans and are based on the effective performance of the major body organs such as the liver, pancreas, heart and kidney. The aim of this study was to establish reference values for renal function test parameters and to determine possible differences between published and local reference ranges
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