Abstract
The metabolism of 3H-corticosterone by C57BL/1OJ and DBA/2J mice has been studied in homogenates of liver from the two strains with and without the addition of a NADPH-generating system. A complete quantitative and structural analysis has been made of reduced metabolites produced by both strains, in the presence or absence of exogenous NADPH. These studies show that 3H-corticosterone is metabolized more efficiently to polar steroids in homogenates of the C57 strain and reveal a strong dependence upon exogenous NADPH for hepatic corticosterone metabolism in the DBA strain that is not apparent in C57. 3H-corticosterone is metabolized by both strains in vitro mainly to mixtures of products that are either reduced in ring A (tetrahydro-derivatives) or reduced both in ring A and at C-20 (hexahydro-derivatives). Among both tetrahydro- and hexahydro-derivatives 3β,5α metabolites predominate in both strains but 3β-reduction and C-20 reduction are markedly more active in the CS7 than in the DBA strain. In both str...
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