Abstract
AbstractTwo [18F]‐labelled analogues of dexetimide, a potent muscarinic cholinergic receptor ligand, have been synthesised in good yields and at high specific activities. Reductive amination of [2‐18F]‐ and [4‐18F]fluorobenzaldehyde with norbenzyldexetimide and sodium cyanoborohydride gave, in a one‐pot reaction, good (≈︁20%) yields of high specific activity [2‐18F]‐ and [4‐18F]fluorodexetimide respectively. The labelled benzaldehydes may be useful synthetic precursors for the radiosyntheses of other complex radiotracers for use with positron emission tomography.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of Labelled Compounds and Radiopharmaceuticals
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.