Abstract

Reduction of lactational performance following bovine TNF-α administration to dairy cows

Highlights

  • Coliform mastitis has adverse effects on the economics of milk production by reducing the quantity and quality of milk (Shuster et al, 1991)

  • A recent study suggested that Tumor Necrosis Factor-α (TNF) plays a vital role in the pathophysiology associated with coliform mastitis and/or acute phase response (Hoeben et al, 2000)

  • Little information has been reported on somatotropin (ST), insulin-like growth factor-1 (IGF-1), cortisol, and thyroid hormones that are important regulators of mammary gland function

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Summary

Introduction

Coliform mastitis has adverse effects on the economics of milk production by reducing the quantity and quality of milk (Shuster et al, 1991). A recent study suggested that Tumor Necrosis Factor-α (TNF) plays a vital role in the pathophysiology associated with coliform mastitis and/or acute phase response (Hoeben et al, 2000). Studies using endotoxin in lactating cows have been reported (Shuster et al, 1991), but the effects of exogenous TNF treatment on hormonal response, lactational performance and mastitic parameters have not yet been studied. The objective of the present study was to investigate some metabolic and hormonal changes and lactational performance during recombinant bovine TNF (rbTNF)-induced acute phase response in lactating cows in order to provide evidence that TNF is an in vivo mediator of mastitis-stimulated systemic changes

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