Abstract
Poor resolution of single photon emission computed tomography (SPECT) has degraded its use in clinical practice. Collimator correction has been shown to improve the reconstructed resolution, but the correction can generate ringing artefacts, which lower image quality. This paper investigates whether Bayesian reconstruction methods could reduce these artefacts. We have applied and tested three Bayesian reconstruction methods: smoothing prior, median root prior, and anatomical prior. To demonstrate the efficacy of these methods, we compared their physical and visual performance both in phantom and patient studies. All the three Bayesian reconstruction methods reduced the collimator correction artefacts. Images reconstructed using the smoothing prior and the median root prior had slightly lower contrast than the standard reconstruction with collimator correction, whereas the anatomical prior produced images with good resolution and contrast.
Highlights
Collimator response correction during iterative single photon emission computed tomography (SPECT) reconstruction has recently gained a lot of attention
This paper investigates whether Bayesian reconstruction methods could reduce these artefacts
Collimator response correction during iterative SPECT reconstruction has recently gained a lot of attention
Summary
Collimator response correction during iterative SPECT reconstruction has recently gained a lot of attention. The collimator response correction has been shown to simultaneously increase reconstructed resolution and lower image noise level [1]. This improvement in resolution-noise tradeoff has further been shown to lead to better lesion detection performance [2, 3] and higher quantitative accuracy [4]. The improved resolution-noise trade-off has given rise to the idea of half-time imaging; that is with the new correction methods it could be possible to acquire data with at least the currently accepted image quality, only at half the acquisition time [5, 6]. Decreased imaging time would allow more patients to be imaged per day or the current imaging time could be kept the same but the injected activity would be reduced to half, which would reduce the radiation dose and the amount of the radiopharmaceutical used
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