Abstract
BackgroundA reduction in adiposity may be associated with an improvement in insulin sensitivity and β-cell function as well as cardiovascular disease (CVD) risk factors; however, few studies have investigated these associations in a longitudinal setting.MethodsTo investigate these associations over a 1-year period, we conducted an observational analysis of 196 Japanese subjects with obesity in the Saku Control Obesity Program. We investigated the relations between changes in adiposity (body mass index [BMI], waist circumference, subcutaneous fat area [SFAT], and visceral fat area [VFAT]) and changes in HbA1c, fasting plasma glucose (FPG), insulin sensitivity index (ISI), the homeostasis model assessment β cell function (HOMA-β), lipids, and blood pressure.ResultsAll adiposity changes were positively associated with HbA1c and FPG changes. Reductions in BMI and VFAT were associated with HOMA-β reduction. Reductions in all adiposity measures were associated with an improvement in the ISI. Changes in most adiposity measures were positively associated with changes in blood pressure and lipid levels, except for LDL.ConclusionThe present findings provide additional supportive evidence indicating that a reduction in adiposity may lead to an improvement in insulin sensitivity and the reduction of CVD risk factors in obese individuals.
Highlights
Since the identification of obesity as the a strong risk factor for various diseases, such as cardiovascular disease (CVD), stroke, and type 2 diabetes, lifestyle modification and weight loss have become major strategies for disease prevention
It has been recognized that a compensatory period exists before the diagnosis of diabetes, and the insulin secretion decreases after the diagnosis of diabetes [11]
We found that reductions in body mass index (BMI), visceral fat area, and waist circumference were associated with a reduction in homeostasis model assessment b cell function (HOMA-b), while no association was observed for the insulinogenic index
Summary
Since the identification of obesity as the a strong risk factor for various diseases, such as cardiovascular disease (CVD), stroke, and type 2 diabetes, lifestyle modification and weight loss have become major strategies for disease prevention. In light of effective diabetes prevention, strategies for preserving b-cell function are of great importance. It is of great interest to investigate whether reduction in adiposity is associated with improvement in insulin secretion as well as insulin resistance. The relationship between the changes in adiposity and insulin resistance or b-cell function has not been well-understood. A reduction in adiposity may be associated with an improvement in insulin sensitivity and b-cell function as well as cardiovascular disease (CVD) risk factors; few studies have investigated these associations in a longitudinal setting
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