Abstract
Several recent studies suggest that vitamin C (ascorbic acid [AA]) status may be altered in insulin-dependent diabetes mellitus (IDDM). We measured the AA content of mononuclear leukocytes (MM-AA) as an indicator of tissue vitamin C status in adults with IDDM and nondiabetic adults matched for age and sex. Dietary vitamin C intake and plasma AA were analyzed to ensure that vitamin C availability was adequate. Dietary vitamin C intakes were above recommendations and were not different between the groups. MN-AA was reduced by 33% on average ( P < .05) in adults with IDDM (1.75 μg/mg total protein [TP]) when compared with nondiabetics (2.60 μg/mg TP). When MN-AA is indexed to the dietary vitamin C intake ( MN-AA 100 mg diet C ), the storage deficit in adults with IDDM averages 50% ( P < .05). This observation suggests an impaired tissue AA storage in adults with IDDM and supports the theory that intracellular scurvy contributes to the chronic degenerative complications of the disease.
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