Reduced handgrip and inspiratory muscle strength are associated with lower lung function and physical capacity in children and adolescents born preterm with very low birth weight.

The objective of this prospective cohort study was to investigate the incidence of intensive care unit (ICU)-acquired weakness (ICUAW) and compare handgrip strength (HGS) and inspiratory muscle strength, measured by maximum inspiratory pressure (MIP), between critical illness survivors with and without ICUAW. Additionally, we examined whether HGS and MIP could serve as surrogate measures for ICUAW and establish reference cut-off values for both HGS and MIP in Taiwanese ICU survivors. A total of 274 ICU survivors aged ≥20 yrs without prior systemic weakness from six medical ICUs at a tertiary care hospital in Taiwan were consecutively enrolled. ICUAW was identified at the time of ICU discharge using standardised manual muscle testing based on the Medical Research Council scale. Simultaneously, HGS and MIP were assessed. A receiver operating characteristic curve analysis was performed to evaluate whether HGS and MIP could serve as surrogate markers for ICUAW and to establish their cut-off values. Among the 406 enrolled participants, 310 survived their ICU stay, and 274 completed the Medical Research Council test upon ICU discharge. The survivors were predominantly male (65.7%), with a median age of 70 years (interquartile range: 59-80). Acute respiratory failure was the leading cause of ICU admission (52.9%), and 60.2% of patients required mechanical ventilation during their ICU stay, with a median duration of 8 days (interquartile range: 3-8). ICUAW was identified in 23.0% of survivors. Fewer participants in the ICUAW group were able to complete HGS (87.1%) and MIP (45.2%) assessments, likely due to physical limitations. Compared with those without ICUAW, the ICUAW group was significantly older, had higher Acute Physiology and Chronic Health Evaluation scores at admission, required longer mechanical ventilation, had longer ICU stays, and displayed weaker HGS and lower MIP at ICU discharge. The receiver operating characteristic curve analysis demonstrated that both HGS and MIP served as promising surrogate markers with areas under the curve of 0.842 and 0.822, respectively, and optimal cut-offs of 10.9 kg-force for HGS and 22.5 cmH2O for MIP. Additionally, sex-specific cut-offs were also identified. HGS and MIP show promise as surrogate markers for ICUAW, with our ICU survivor cohort revealing comparable HGS and lower MIP cut-off values compared to previous recommendations. These results emphasise the importance of tailored cut-offs and screening approaches for different ethnic and geographic regions. Additionally, they provide preliminary reference values for ICU survivors in Taiwan and highlight the need for further studies in the region.

Purpose Limited number of studies investigated the effects of Electrostatic powder paints (EPP) on human health. We investigated the effects of EPP exposure on lung function, exercise capacity, and quality of life, and the factors determining exercise capacity in EPP workers. Methods Fifty-four male EPP workers and 54 age-matched healthy male individuals (control group) were included. Lung function and respiratory muscle strength were measured. The lower limit of normal (LLN) cut-points for FEV1 and FEV1/FVC were calculated. An EPT was used to evaluate bronchial hyperactivity. The handgrip and quadriceps muscle strength were evaluated using a hand-held dynamometer. An ISWT was used to determine exercise capacity. The physical activity level was questioned using the IPAQ. The SGRQ and NHP were used to assessing respiratory specific and general quality of life, respectively. Results Duration of work, FEV1, MIP, handgrip strength, and ISWT distance were significantly lower, and the change in FEV1 after EPT and %HRmax were significantly higher in the EPP group compared to the control group (p < 0.05). There were no subjects with a < LLN for FEV1 and FEV1/FVC in both groups. In the EPP group, ISWT distance was significantly related to age, height, duration of work, FEV1, change in FEV1 after EPT, MIP, MEP, handgrip strength, IPAQ, SGRQ, and NHP total scores (p < 0.05). The change in FEV1 after EPT, MIP, and duration of work explained % 62 of the variance in the ISWT distance (p < 0.001). Conclusions Changes in lung function based on LLN for the FEV1 and FEV1/FVC were not clinically relevant in EPP workers. Exercise capacity is impaired in EPP workers. Degree of exercise-induced bronchospasm, inspiratory muscle strength, and duration of work are the determinants of exercise capacity in EPP workers.

ObjectivePseudomonas aeruginosa has been suggested as a major determinant of poor pulmonary outcomes in cystic fibrosis (CF), although other factors play a role. Our objective was to investigate the association of early childhood Pseudomonas infection on differences in lung function in adolescence with CF.MethodsTwo populations of subjects with CF were studied: from the Gene Modifier Study (GMS), 346 F508del homozygotes with severe vs. mild adolescent lung disease, and from the Colorado Newborn Screen Study (NBS) 172 subjects diagnosed with CF by newborn screening. Associations of Pseudomonas infection and lung function in early childhood with lung function in adolescence were investigated using multivariate linear regression analyses.ResultsAmong GMS subjects, those with severe adolescent lung disease had worse lung function in childhood (FEV1 25 percentage points lower) compared to subjects with mild adolescent lung disease, regardless of early childhood Pseudomonas status. Among NBS subjects, those with lowest adolescent lung function had significantly lower early childhood lung function and faster rate of decline in FEV1 than subjects with highest adolescent lung function; early Pseudomonas infection was not associated with rate of FEV1 decline. The strongest predictor of adolescent lung function was early childhood lung function. Subjects with a higher percentage of cultures positive for Pseudomonas before age 6 or a lower BMI at 2–4 years old also had lower adolescent lung function, though these associations were not as strong as with early childhood lung function.ConclusionsIn separate analyses of two distinct populations of subjects with CF, we found a strong correlation between lower lung function in early childhood and adolescence, regardless of early childhood Pseudomonas status. Factors in addition to early Pseudomonas infection have a strong impact on lung function in early childhood in CF. Further exploration may identify novel underlying genetic or environmental factors that predispose children with CF to early loss of lung function.

Asthma is associated with impaired lung function; however, it is uncertain if a lower childhood lung function is associated with asthma onset and persistence during adolescence. The aims of the present study were to investigate the association between childhood lung function and onset and persistence of asthma during adolescence. In the population-based BAMSE (Sweden), PIAMA (Netherlands) and MAAS (UK) birth cohorts, we analysed the association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC and forced expiratory volume at 75% of FVC at age 8 years with asthma onset and persistence in adolescence (age 12-16 years) using cohort-specific logistic regression analysis followed by meta-analysis. In the BAMSE, PIAMA and MAAS cohorts, asthma incidence in adolescence was 6.1% (112/1824), 3.4% (36/1050) and 5.0% (39/779), respectively. Persistent asthma from childhood to adolescence was observed in 8.2%, 6.4% and 7.7% of all subjects within the respective cohorts. A higher FEV1 % predicted and FEV1/FVC at age 8 years was associated with a lower odds for adolescent-onset asthma: OR 0.98 (95% CI 0.97-1.00) and 0.97 (0.94-0.99). These associations remained significant also when restricting the analyses to subjects with no wheezing or asthma treatment in childhood. A higher FEV1/FVC at age 8 years was associated with a lower odds for asthma persistence in adolescence (0.96 (0.93-0.99)). Sex by lung function interaction analysis was not significant. A higher lung function at school age was associated with a lower risk of adolescent-onset asthma, predominantly in males. This indicates that a lower lung function in childhood may precede and or potentially contribute to asthma incidence and persistence.

Peripheral muscle strength and lung function in adults with cystic fibrosis.

Purpose: Composite measures have potential to account for many of the facets of disease in chronic obstructive pulmonary disease (COPD). The purpose of this study was to investigate the relationship between the DOSE (Dyspnea, Obstruction, Smoking, Exacerbation) Index which is a multi-component assessment tool and handgrip and respiratory muscle strength, activities of daily living (ADL) and health-related quality of life in patients COPD. Methods: Forty-five patients with COPD (30 males, 15 females, mean FEV1 =50.60±16.00%) were included. The DOSE Index was calculated using the modified Medical Research Council dyspnea scale, obstruction level, smoking status, and exacerbation rate. Inspiratory and expiratory muscle strength (MIP and MEP) was measured using a mouth-pressure device. Handgrip strength was determined using hand dynamometer. Activities of daily living were evaluated using the London Chest Activity of Daily Living Scale (LCADL), and quality of life was assessed using the diseasespecific COPD Assessment Test (CAT). Results: The DOSE Index score was related with handgrip strength (r=-0.388, p=0.009), MIP (r=- 0.323, p=0.033), LCADL-physical activity score (r=0.314, p=0.038), LCADL-leisure activities score (r=0.397, p=0.008), and CAT score (r=0.435, p=0.003). Conclusion: Increased multi-component disease severity is related to decreased handgrip and respiratory muscle strength, physical activity and leisure time activities of daily living, and worse health-related quality of life in COPD patients. The DOSE Index, a simple disease severity assessment tool, is a convenient and practical tool for assessment in pulmonary rehabilitation programs.

Skeletal Muscle Weakness: A Novel Treatable Trait in Asthma?

<b>Prediction of adolescent asthma outcomes using childhood lung function</b> <b>Background:</b> Asthma is associated with a low lung function; however, it is uncertain if a low childhood lung function precedes asthma onset and persistence in adolescence. <b>Aim:</b> We aimed to investigate the association between childhood lung function and onset and persistence of asthma in adolescence. <b>Method:</b> In the BAMSE (Sweden) and PIAMA (Netherlands) birth cohorts, we analyzed the association of FEV₁, FVC, FEV₁/FVC at age 8 with asthma onset and persistence in adolescence (age 12-16) using cohort-specific logistic regression analysis adjusted for BMI, socio-economic status and allergic sensitization followed by meta-analysis. Given sex-differences in lung function and asthma prevalence, we stratified for sex. <b>Results:</b> In the BAMSE and PIAMA cohorts, 6.1% (112/1824) and 3.4% (36/1049) of subjects developed asthma during adolescence and 8.2% and 6.4% had persistent asthma. In the non-stratified analysis, childhood lung function was not associated with adolescent-onset or persistence of asthma. In males, meta-analysis of BAMSE and PIAMA results showed that a higher FEV₁% and FEV₁/FVC were associated with a lower odds of adolescent onset asthma (OR: 0.97 (95% CI:0.95–0.99), p= 0.029, 0.95 (0.91–0.99) p= 0.028). In the BAMSE cohort, a higher FEV₁% was associated with a lower odds of asthma persistence in males (0.96 (0.92–0.99) p=0.031). Childhood lung function was not associated with asthma onset or persistence in females. <b>Conclusion:</b> Our findings show that lower lung function was present before asthma onset in adolescence and that these associations are mainly seen in males. Low lung function in childhood may contribute to asthma onset and persistence.

The Editors' Choice

Background/Aims Shoulder pain is reported to be the third most common musculoskeletal disorder. Rotator cuff muscles play an important role in stabilising the shoulder and decreasing pain. Assessment of handgrip strength has been proposed as an indicator of rotator cuff function in healthy individuals, but not in those experiencing shoulder pain. The aim of this study was to assess the relationship between handgrip strength and shoulder rotator cuff strength in patients experiencing shoulder pain as a result of pathology or surgical intervention. A secondary aim was to identify any association between the duration of shoulder pain and handgrip strength and shoulder rotator cuff strength. Methods A total of 32 patients with shoulder pain (19 men, 13 women) were evaluated. The mean age was 52.88 (± 15.66) years, with a mean duration of shoulder pain of 13.44 (± 10.22) weeks. Handgrip strength was measured using the standard Jamar hydraulic hand dynamometer, and individual isometric rotator cuff strength was measured using the Baseline push-pull dynamometer. Results Correlation was found between handgrip strength and the abductor (r=0.58), external rotator (r=0.57), and internal rotator strength (r=0.59). A linear regression model was used to derive the equations for the association. No significant (P&gt;0.05) correlation was found between the duration of pain and the handgrip strength or rotator cuff strength. Conclusions The strength of the correlation found indicates that handgrip strength can be used for assessment and within a rehabilitation programme to monitor rotator cuff function in patients with shoulder pain or post-surgical rehabilitation. The strength of rotator cuff muscles can be predicted by the equations derived from the regression model relating to grip strength assessment.

Pulmonary function tests may predict future outcomes; however, they are not often performed in middle-aged individuals at risk for future airway obstruction. We examined whether smokers with low lung function (LLF) have an increased risk of developing health problems and mortality over time. Current and ever smokers (n=830) from the Lovelace Cohort aged 40-60 years without baseline airway obstruction and with at least 2 spirometry measurements over 18 months were included. Participants were divided into high lung function (HLF) and LLF function tertiles based on forced expiratory volume in 1 second percentage predicted (FEV1%pred). Lung function, health status, and comorbidities were compared at baseline and over 17 years; mortality at 17 years was also assessed. From these participants, 61 HLF (baseline FEV1%pred >99%) and 26 LLF (baseline FEV1%pred <88%) were examined at 17 years follow-up using logistic regression. Baseline demographic and clinical characteristics were generally similar between the LLF and HLF tertiles, except for age, sex, body mass index, and lung function. In the overall cohort (LLF, n=277; HLF, n=277), survival of the HLF versus LLF cohort showed a hazard ratio of 0.49 (p=0.02). At the 17-year follow-up, LLF was associated with increased prevalence of wheeze, cardiovascular diseases, chronic lung diseases, diabetes, and worse health status. Smokers with LLF without airflow obstruction exhibited reduced survival and an increased risk for development of chronic morbidities. Thus, spirometry may be used to identify at-risk individuals, allowing for early preventative interventions that can improve long-term health outcomes. Take home message: Among ever smokers without airflow obstruction, LLF is associated with increased mortality and poor health status. Spirometry may identify at-risk patients, enabling early emphasis on interventions with the potential to improve long-term health outcomes.

BackgroundThe association between handgrip strength and lung function has been explored in previous studies, yet few studies have addressed how this relationship varies by sex and age in healthy populations. Additionally, few studies have investigated the utility of the lower limit of normal (LLN) for identifying abnormal lung function in relation to handgrip strength. This study aimed to evaluate sex- and age-specific associations between handgrip strength and lung function in a healthy adult population.MethodsThis cross-sectional study included individuals undergoing health check-ups at a regional hospital in Japan from April 2018 to March 2020. Data on demographics, anthropometrics, handgrip strength, spirometry, and lifestyle factors were collected. Handgrip strength was assessed using a digital dynamometer, with two measurements taken for each hand while keeping the arms straight down at the sides without touching the body. The highest recorded value from each hand was averaged as the final measure. Pearson’s correlation and multiple regression analyses were conducted to explore the relationship between handgrip strength and lung function parameters. Logistic regression analyses were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for abnormal lung function per 5 kg increase in handgrip strength.ResultsA total of 1622 individuals were included in the study. The correlation coefficients between handgrip strength and forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were approximately 0.3-0.45 (p < 0.01) after stratification by sex. Linear regression analysis showed a positive association between handgrip strength and FEV1, percentage of the predicted FEV1 value (FEV1% predicted), FVC, and percentage of the predicted FVC value (FVC% predicted) across all age groups in women (p < 0.05). In men, these associations were significant in the 25-44 and 45-59 year age groups (p < 0.05). Logistic regression indicated that a 5 kg increase in handgrip strength was significantly associated with reduced abnormal lung function in both men (OR = 0.790, 95% CI = 0.673-0.927; p < 0.01) and women (OR = 0.598, 95% CI = 0.461-0.775; p < 0.01); however, the significance was nullified in men over 60 years of age after further age stratification.ConclusionHandgrip strength is positively associated with FEV1 and FVC, both in absolute and predicted percentage values, across all age groups in women and in men under 60 years of age. A 5 kg increase in handgrip strength is significantly associated with lower abnormal lung function in women. Handgrip strength measurements integrated into regular health checkups may help in the early detection of lung function abnormalities, even in early adulthood. Further longitudinal studies are warranted to validate these findings.

SUMMARY We described levels of habitual physical activity and physical capacity in HIV patients initiating antiretroviral treatment in Ethiopia and assessed the role of HIV and nutritional indicators on these outcomes. Physical activity energy expenditure (PAEE) and activity levels were measured with combined heart rate and movement sensors. Physical capacity was assessed by grip strength, sleeping heart rate and heart rate economy. Grip strength data was also available from a sex- and age-matched HIV-negative reference group. Median PAEE was 27.9 (interquartile range 17.4-39.8) kJ/kg per day and mean ± s.d. grip strength was 23.6 ± 6.7 kg. Advanced HIV disease predicted reduced levels of both physical activity and capacity; e.g. each unit viral load [log(1+copies/ml)] was associated with -15% PAEE (P < 0.001) and -1.0 kg grip strength (P < 0.001). Grip strength was 4.2 kg lower in patients compared to HIV-negative individuals (P < 0.001). Low body mass index (BMI) predicted poor physical activity and capacity independently of HIV status, e.g. BMI <16 was associated with -42% PAEE (P < 0.001) and -6.8 kg grip strength (P < 0.001) compared to BMI ≥18.5. The study shows that advanced HIV and malnutrition are associated with considerably lower levels of physical activity and capacity in patients at initiation of antiretroviral treatment.

Persistent short stature, other potential outcomes, and the effect of growth hormone treatment in children who are born small for gestational age.

Whether upper-extremity and lower-extremity muscle strength can predict a prognosis of congestive heart failure (CHF) patients is unclear. This study evaluated the impact of muscle strength on long-term mortality in patients with CHF. Prospective observational study of male Japanese CHF patients. Clinical characteristics (age, body mass index, left ventricular ejection fraction, heart failure etiology, and medications) were obtained from hospital records of 148 male outpatients with stable CHF. Brain natriuretic peptide was determined as an index of disease severity. Peak oxygen uptake ((Equation is included in full-text article.)), handgrip, and knee extensor muscle strength were also determined. After 1331.9+/-700.3 days of follow-up, 13 cardiovascular-related deaths occurred, and the patients were divided into two groups: survival (n=135) and nonsurvival (n=13). No significant differences were found between the groups in clinical characteristics, brain natriuretic peptide levels, and knee extensor muscle strength. Peak(Equation is included in full-text article.)(P=0.011) and handgrip strength (P=0.008) were significantly lower in the nonsurvival versus survival group. Left ventricular ejection fraction, peak(Equation is included in full-text article.), and handgrip strength were found by univariate Cox proportional hazards analysis to be significant prognostic indexes of survival. Multivariate analysis, however, revealed handgrip strength to be an independent predictor of prognosis. A handgrip strength cutoff value of 32.2 kgf was determined by the analysis of receiver-operating characteristics and was assessed. Kaplan-Meier survival curves after log-rank test showed significant prognostic difference between the two groups (P=0.008). Handgrip strength may be useful for forecasting prognosis in patients with CHF.