Abstract
Objective: In this study, we collected samples from postmenopausal women aged >60 y and evaluated bone mineral density (BMD) in addition to other biochemical variables to evaluate risk factors for osteoporosis. Furthermore, we investigated whether an association exists between the CpG island methylation levels in the promoter region of the TBC1D8 gene and osteoporosis incidence. Our goal was to identify contributing factors to the pathogenesis of osteoporosis and provide a theoretical basis for osteoporosis testing and therapy.Materials and Methods: We used questionnaires to collect data from Chinese Han women in their communities. The following parameters were measured: uric acid, high density lipoprotein, low density lipoprotein, fasting blood glucose, serum creatinine, serum calcium, serum phosphorus, alkaline phosphatase, P1NP, β-CTX, PTH, 25(OH)D and bone mineral density from lumbar spine 1 to 4, femoral neck, and total hip. DNA was also extracted to assess the methylation level of the TBC1D8 gene.Conclusions: Our findings suggest that a lower body mass index (BMI) infrequent exercise and certain sleep durations may be associated with osteoporosis. In addition, higher serum creatinine, β-CTX and PTH and lower 25(OH)D levels may be associated with osteoporosis. In Chinese Han postmenopausal women, decreased methylation of the TBCF1D8 gene promoter CpG islands is associated with osteoporosis. Finally, we also observed that TBC1D8 is negatively correlated with high density lipoprotein in postmenopausal women with osteoporosis.
Highlights
Osteoporosis is a metabolic bone disease characterized by increased bone strength and increased risk for fracture
Our findings suggest that a lower body mass index (BMI) infrequent exercise and certain sleep durations may be associated with osteoporosis
Higher serum creatinine, β-CTX and parathyroid hormone (PTH) and lower 25(OH)D levels may be associated with osteoporosis
Summary
Osteoporosis is a metabolic bone disease characterized by increased bone strength and increased risk for fracture. Osteoporosis is classified as either primary or secondary. Primary osteoporosis occurs in people of all ages, but most commonly in postmenopausal women and elderly men. Secondary osteoporosis occurs in response to drugs, other diseases and additional factors [1]. Osteoporosis often causes pain in the back, shortening of the body length, kyphosis, and decreased respiratory function. Patients may experience osteoporotic fractures, which cause physical and mental anguish and increase economic burden. Osteoporosis, diabetes and cardiovascular disease are considered the three major pathologies in the elderly by the World Health Organization (WHO)
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