Abstract
Global climate deterioration intensifies the demand for exploiting efficient CO2 utilization approaches. Converting CO2 to biorefinery feedstock affords an alternative strategy for third-generation biorefineries. However, upcycling CO2 into complex chiral carbohydrates remains a major challenge. Previous attempts at sugar synthesis from CO2 either produce mixtures with poor stereoselectivity or require ATP as a cofactor. Here, by redesigning glycolaldehyde synthase, the authors constructed a synthetic pathway for biorefinery feedstock D-xylulose from CO2 that does not require ATP as a cofactor. The artificial D-xylulose pathway only requires a three-step enzyme cascade reaction to achieve the stereoselective synthesis of D-xylulose at a concentration of 1.2gL-1. Our research opens up an alternative route toward future production of chemicals and fuels from CO2.
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