Abstract
The levels of reduced glutathione in the red cells of 64 untreated patients suffering from tobacco amblyopia, who had normal vitamin B12 status, were found to be significantly lower than those found in 54 normal, healthy control subjects. Treatment of 17 other tobacco amblyopia patients with intramuscular hydroxocobalamin, oral hydroxocobalamin or oral cystine resulted in increases in red cell glutathione towards normal levels. These methods of treatment have also been shown to cause increases in plasma and urinary thiocyanate concentrations with accompanying improvement in vision. It is suggested that reduced glutathione may play an important part in the conversion of cyanide to thiocyanate.
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