Abstract
BackgroundTo evaluate the relationship between red blood cell distribution width (RDW) and carotid intima-media thickness (CIMT) in metabolic syndrome (MetS) patients.MethodsIn this study, we analyzed 803 patients with MetS who underwent carotid ultrasonography examination at Henan Province Hospital of Traditional Chinese Medicine from October 2014 to September 2015. Demographic data were collected using a questionnaire. An automatic biochemistry analyzer measured RDW. Pearson correlation coefficient, multivariate linear and logistic regression was used to evaluate the correlation between RDW and CIMT.ResultsCompared with control group, case group had higher RDW level (P < 0.001) and CIMT (P < 0.001). CIMT was positively related to RDW (r = 0.436, P < 0.001). Logistic regression indicated that RDW was a predictor of CIMT ≥ 1 mm. Compared with the first quartile, people with third and fourth quartile level gave obvious higher risk of carotid artery atherosclerotic trend (OR = 1.41, 95% CI:1.01–197; OR = 2.10, 95% CI: 1.30–3.40). Using a cutoff point of 13.9%, RDW predicts elevated CIMT with a sensitivity of 62.1% and a specificity of 70.3%.ConclusionHigh RDW is related to the increased CIMT in MetS patients, which highlights the role of RDW in the progression of elevated CIMT in MetS patients.
Highlights
To evaluate the relationship between red blood cell distribution width (RDW) and carotid intimamedia thickness (CIMT) in metabolic syndrome (MetS) patients
The case group has significantly higher RDW level and CIMT compared with the control group
The present study finds that patients with CIMT > 1 mm have higher RDW than those with CIMT ≤ 1 mm, and the elevated RDW is associated with increased CIMT, independent of a number of potential confounding factors
Summary
To evaluate the relationship between red blood cell distribution width (RDW) and carotid intimamedia thickness (CIMT) in metabolic syndrome (MetS) patients. Metabolic syndrome (MetS) is characterized by a cluster of obesity, hypertension, and dyslipidemia-diabetes. It has emerged as a global health issue that affects about 20–30% of adults in many countries [1,2,3]. Previous studies suggest that MetS is related to adverse cardiovascular outcomes [4]. Carotid artery atherosclerosis is fprogressive disease caused by thickened carotid intimamedia thickness (CIMT). The clinical symptoms of thickened CIMT are usually not obvious in MetS patients [8].
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