Abstract

Clinically, red blood cell abnormalities are closely related to tumor diseases, red blood cell diseases, internal medicine, and other diseases. Red blood cell classification is the key to detecting red blood cell abnormalities. Traditional red blood cell classification is done manually by doctors, which requires a lot of manpower produces subjective results. This paper proposes an Attention-based Residual Feature Pyramid Network (ARFPN) to classify 14 types of red blood cells to assist the diagnosis of related diseases. The model performs classification directly on the entire red blood cell image. Meanwhile, a spatial attention mechanism and channel attention mechanism are combined with residual units to improve the expression of category-related features and achieve accurate extraction of features. Besides, the RoI align method is used to reduce the loss of spatial symmetry and improve classification accuracy. Five hundred and eighty eight red blood cell images are used to train and verify the effectiveness of the proposed method. The Channel Attention Residual Feature Pyramid Network (C-ARFPN) model achieves an mAP of 86%; the Channel and Spatial Attention Residual Feature Pyramid Network (CS-ARFPN) model achieves an mAP of 86.9%. The experimental results indicate that our method can classify more red blood cell types and better adapt to the needs of doctors, thus reducing the doctor's time and improving the diagnosis efficiency.

Highlights

  • IntroductionBlood has the following four forms, namely white blood cells (WBCs), red blood cells (RBCs), platelets, and plasma

  • As a connective tissue, blood has the following four forms, namely white blood cells (WBCs), red blood cells (RBCs), platelets, and plasma

  • It can be seen that the CS-Attention-based Residual Feature Pyramid Network (ARFPN) model achieves better performance

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Summary

Introduction

Blood has the following four forms, namely white blood cells (WBCs), red blood cells (RBCs), platelets, and plasma. The other three types of cells can be distinguished according to their shape, size, presence or absence of nucleus, color, and texture [1]. RBCs are the majority component of blood cells, which transport oxygen to various parts of the human body and discharge the carbon dioxide produced by the human body [2, 3]. The morphology of RBCs is non-nucleated, with biconvex and concave round pie-shaped cells. Its average diameter and thickness of this type of cell are about 7 and 2.5 μm, respectively. The average life span of RBCs is about 120 days, and abnormal RBCs may live

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