Abstract
Recurrent respiratory papillomatosis (RRP) is a viral-induced disease that most commonly affects the upper aerodigestive tract of adults and children. The manifestations and clinical course of RRP differ based on the age of onset. Childhood-onset RRP is more aggressive and more common than its adult counterpart. In children, the disease is usually acquired at birth from a mother infected with human papillomavirus in the urogenital tract. Adults typically acquire RRP through sexual contact. The course of the disease is variable, but many patients, usually children, require multiple surgical procedures to maintain a patent airway. Several adjuvant therapies have been studied, including the use of interferon, photodynamic therapy, indole-3-carbinol, and cidofovir, although none has been shown to eliminate the disease. In this review, we discuss what is presently known regarding the etiology, transmission, clinical course, and treatment options of RRP.
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