Abstract
While it is widely believed that lipid and protein components in membranes exhibit lateral organization on a length scale comparable to molecular dimensions, this has been very difficult to characterize. Fluorescent or spin label labels have been used, however, especially for lipids, these probes may perturb the delicate interactions responsible for lateral heterogeneity. We have developed imaging mass spectrometry using the Cameca NanoSIMS 50L to probe composition in model membranes using only non-perturbing isotopic labels.
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