Abstract
The effects of recombinant lymphotoxin (rLT) and tumor necrosis factor (rTNF) on the growth of clonogenic normal and leukemic hematopoietic cells were investigated. Two opposite and dose-dependent effects of rLT on normal CFU-GM were found. Low concentrations (5 pM) did stimulate the growth, while higher amounts of rLT showed an antiproliferative effect. In contrast, the effect of rTNF was only an inhibition of growth in a dose-dependent fashion. In chronic myeloid leukemia (CML), the CFU-GM was resistant to the growth stimulatory effect of rLT. Furthermore, CML-cells were found to be more susceptible than normal CFU-GM to the antiproliferative effect of both rLT and rTNF. These results show that LT and TNF exhibit qualitative differences in the effects on hematopoietic cells and that CML-cells display an increased susceptibility for the cytostatic effects on LT and TNF.
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