Abstract
Nature is continuously giving us a wide variety of molecules with a great therapeutic potential that are able to fulfill protection, in humans, from anticancer and antibacterial to antioxidant or anti-inflammatory. Unfortunately, almost all plant-derived biomolecules have a low physiological stability, reduced bioavailability, a prolonged circulation time in the blood, or non-selectivity regarding the target tissue. Furthermore, the oral administration of plant-derived biomolecules proved not to be always efficient, only if high doses are applied. Lately, a lot of effort is given to find novel technologies to provide them protection till the target site is reached, by their entrapment inside a properly engineered system.Current review is focused on the existent microencapsulation technologies of plant-derived bioactive compounds, offering details about main steps of the fabrication processes used to obtain a high encapsulation efficiency. A special attention was offered to specific cellular uptake, intracellular localization and transport of micro delivery systems, but also to their therapeutic potential that could be a promising approach for the treatment of various chronic diseases. An outlook into future research on novel microcapsules for biomedical and pharmaceutical applications is also provided.
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