Abstract

C-glycosylation through the formation of glycosyl radical is a very feasible and expedient approach for making of the C–C anomeric bond. In this light, this review article is covering selected literature from 2000 to 2022 on the synthetic development of C-glycosylation involving the generation of glycosyl radical as a crucial intermediate in a stereoselective fashion. The generation of glycosyl radical is controlled by the reaction method applying to the radical precursor. Those methods are categorized in terms of a key source of an initiator such as metal-free activation of radical precursor, photochemical induced approach, and metal-mediated approach including transition metal-mediated, lanthanide, and non-transition metal-mediated approach with brief mechanistic discussion, and stereochemical outcome of resultant C-glycosides in detail. This brief discussion accumulates the stereoselective synthesis of challenging C-linked building blocks in a more facile way via generation of glycosyl radical and those building blocks have a great role as drugs, inhibitors, glycoconjugates in the field of biological and medicinal chemistry.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call