Abstract
Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is an oncogenic human herpesvirus. KSHV is associated with three cancers in the human population: KS, primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). KS is the leading cause of cancer in HIV-infected individuals. In this review, we discuss the most recent discoveries behind the mechanisms of KSHV latency maintenance and lytic replication. We also review current therapies for KSHV-associated cancers.
Highlights
Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV), known as human herpesvirus 8 (HHV-8), is a linear double-stranded DNA virus and a member of the gammaherpesvirus subfamily
Kaposi’s sarcoma-associated herpesvirus (KSHV) is linked to two under-studied inflammatory syndromes
The virus goes latent and expresses only a few proteins and microRNAs. This latent virus can be reactivated and enter the lytic cycle through either cellular stress or chemical induction that alters the epigenetics of the cell
Summary
F1000 Faculty Reviews are written by members of the prestigious F1000 Faculty. They are commissioned and are peer reviewed before publication to ensure that the final, published version is comprehensive and accessible. The reviewers who approved the final version are listed with their names and affiliations. Any comments on the article can be found at the end of the article
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