Recent Advances in the Synthesis of Heterocyclic Compounds Using Flash Vacuum PyrolysisaaDedicated to the memory of two major figures in this field of research: Gloria Inés Yranzo (1957–2008) and Hamish McNab (1949–2010).

Abstract

Abstract Applications of flash vacuum pyrolysis to the synthesis of heterocyclic compounds published between 2000 and 2015 are described in six major sections with 150 literature references. The emphasis is on methods suitable for preparation of stable heterocyclic products in multi-gram quantities. Consideration of the relatively few reports of synthesis of three- and four-membered rings is followed by the largest single section on the synthesis of five-membered rings, mainly those containing one or two nitrogen atoms. A further major section discusses synthesis of six-membered ring products, again predominantly containing nitrogen, before the final shorter sections on seven-membered, eight-membered, and larger rings.