Abstract
Polyhydroxyalkanoates (PHAs) are biodegradable polyesters that can be produced by a wide variety of microorganisms as a carbon storage material. PHAs have a large range of physical properties that are influenced by the side chain length of the repeating units and the variety of those repeating units in a given polymer. The physical properties can range from strong and stiff to elastomeric in nature, making PHAs desirable materials for numerous applications including use as thermoplastics and in medical applications. Our focus here is on the recent advances in PHA biosynthesis in recombinant Escherichia coli. Since E. coli does not natively produce PHAs, it is incapable of degrading the PHAs once they are synthesized, and it lacks transcriptional and translational regulatory factors that are present in native PHA producers, making it an ideal strain for PHA production. Numerous factors are of crucial consideration in PHA production in E. coli, and we have demonstrated improvements in multiple areas via enzyme and metabolic pathway engineering.
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