Abstract
Lysine specific demethylase 1 (LSD1), a flavin adenine dinucleotidedependent demethylase, specifically catalyzes the demethylation of mono- and di-methylated histone H3 lysine 4 (H3K4) and histone H3 lysine 9 (H3K9)as well as functionally regulates target gene expression. Studies have shown that LSD1 is highly expressed in many malignant tumors and closely related to tumorigenesis, proliferation, invasion and metastasis. Therefore, LSD1 and its inhibitors have recently emerged as sharp research focus. In this review, the authors address the new research findings among the LSD1 inhibitors and tumor therapy. Key words: Lysine specific demethylase 1; Inhibitors; Tumor therapy
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