Abstract
Osteoclasts are primary cells for bone resorption, and their differentiation is tightly regulated by receptor activator of nuclear factor kappa B ligand (RANKL) and a transcription factor nuclear factor-activated T cells (NFAT) c1. Recent studies have uncovered that the epigenetic regulation such as DNA methylation, histone methylation and acetylation, and micro RNAs play a critical role in cell differentiation. In particular, the expression of key developmental genes tends to be tightly regulated by trimethylation of histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3). Several reports have been proposed regarding the epigenetic regulation of osteoclast differentiation including this specific histone modification change. RANKL-induced NFATc1 expression is associated with the demethylation of H3K27me3 in osteoclast precursors. Jumonji domain containing-3 (Jmjd3), a H3K27 demethylase, is induced in murine bone marrow-derived macrophages in response to RANKL stimulation, and supposedly plays a critical role in the demethylation of H3K27me3 in the Nfatc1 gene and osteoclast differentiation. Keywords: Epigenetics, Histone Modification, Jmjd3, Osteoclast differentiation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
