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Real-Time Dynamic Ultrasound Characteristics of the Thyrohyoid Space in Vocal Hyperfunction Mode.

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To explore the clinical value of real-time ultrasound measurement of thyrohyoid space dynamics in assessing vocal hyperfunction mode (VHM). The 161 chronic laryngitis patients, 55 with vocal cord polyps, and 44 normal controls were studied at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, from June 2024 to January 2025. Voice quality, aerodynamic parameters, and thyrohyoid space were assessed using VHI-10, GRBAS scale, voice analysis, aerodynamic profiling, palpation scoring, and ultrasound. Data analysis was conducted using Python. Significant differences (p < 0.05) in VHI-10 scores, G, R, B, S, Jitter, and Shimmer are observed between male and female vocal cord polyp groups. Aerodynamic analysis indicates distinct variations in mean airflow rate across both genders (p < 0.05), while maximum phonation time and subglottic pressure differ significantly in females alone (p < 0.05). Palpation scores for the thyrohyoid space and F0 do not show substantial differences (p > 0.05) between groups. Conversely, real-time ultrasound evaluations of the thyrohyoid space, including pre-phonation/phonation minimum distances (left/right), rates of unilateral (left/right) narrowing, and maximum narrowing rate, exhibit notable differences (p < 0.05) across three groups. Real-time ultrasound measurement of the thyroid-hyoid gap is simple, feasible, and provides a more quantitative assessment of VHM than subjective palpation or vocal aerodynamic measures. It therefore represents a useful clinical tool for evaluating voice function.

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  • Feb 24, 2023
  • Circulation: Cardiovascular Imaging
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  • Research Article
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  • 10.1111/jocs.13967
Sinus node artery aneurysm arising from the left main coronary artery with a fistula into the right atrium.
  • Dec 30, 2018
  • Journal of cardiac surgery
  • Jingjing Huang + 4 more

Journal of Cardiac SurgeryVolume 34, Issue 1 p. 37-40 IMAGES IN CARDIAC SURGERY Sinus node artery aneurysm arising from the left main coronary artery with a fistula into the right atrium Jingjing Huang MD, Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, ChinaSearch for more papers by this authorKuan Zeng MD, PhD, Cardiovascular Surgery Department, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, ChinaSearch for more papers by this authorYanqi Yang MD, PhD, Corresponding Author yanqiyang_lio@yahoo.se Cardiovascular Surgery Department, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China Correspondence Wang Jingfeng MD, PhD and Zhang Yuling MD, PhD, Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, the West of Yanjiang Road, Yuexiu District, Guangzhou 510120, China. Email: drwjf@hotmail.com (W.J.); zzhangyuling@126.com (Z.Y.) Yang Yanqi MD, PhD, Cardiovascular Surgery Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, the West of Yanjiang Road, Yuexiu District, Guangzhou 510120, China. Email: yanqiyang_lio@yahoo.seSearch for more papers by this authorYuling Zhang MD, PhD, Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, ChinaSearch for more papers by this authorJingfeng Wang MD, PhD, Corresponding Author drwjf@hotmail.com orcid.org/0000-0002-4710-0370 Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China Correspondence Wang Jingfeng MD, PhD and Zhang Yuling MD, PhD, Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, the West of Yanjiang Road, Yuexiu District, Guangzhou 510120, China. Email: drwjf@hotmail.com (W.J.); zzhangyuling@126.com (Z.Y.) Yang Yanqi MD, PhD, Cardiovascular Surgery Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, the West of Yanjiang Road, Yuexiu District, Guangzhou 510120, China. Email: yanqiyang_lio@yahoo.seSearch for more papers by this author Jingjing Huang MD, Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, ChinaSearch for more papers by this authorKuan Zeng MD, PhD, Cardiovascular Surgery Department, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, ChinaSearch for more papers by this authorYanqi Yang MD, PhD, Corresponding Author yanqiyang_lio@yahoo.se Cardiovascular Surgery Department, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China Correspondence Wang Jingfeng MD, PhD and Zhang Yuling MD, PhD, Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, the West of Yanjiang Road, Yuexiu District, Guangzhou 510120, China. Email: drwjf@hotmail.com (W.J.); zzhangyuling@126.com (Z.Y.) Yang Yanqi MD, PhD, Cardiovascular Surgery Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, the West of Yanjiang Road, Yuexiu District, Guangzhou 510120, China. Email: yanqiyang_lio@yahoo.seSearch for more papers by this authorYuling Zhang MD, PhD, Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, ChinaSearch for more papers by this authorJingfeng Wang MD, PhD, Corresponding Author drwjf@hotmail.com orcid.org/0000-0002-4710-0370 Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China Correspondence Wang Jingfeng MD, PhD and Zhang Yuling MD, PhD, Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, the West of Yanjiang Road, Yuexiu District, Guangzhou 510120, China. Email: drwjf@hotmail.com (W.J.); zzhangyuling@126.com (Z.Y.) Yang Yanqi MD, PhD, Cardiovascular Surgery Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, the West of Yanjiang Road, Yuexiu District, Guangzhou 510120, China. Email: yanqiyang_lio@yahoo.seSearch for more papers by this author First published: 30 December 2018 https://doi.org/10.1111/jocs.13967Citations: 1 Jingjing Huang and Kuan Zeng are co-first author should be addressed. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Citing Literature Volume34, Issue1January 2019Pages 37-40 RelatedInformation

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  • 10.3760/cma.j.issn.1673-0860.2012.10.015
Role of aerodynamic parameters in voice function assessment
  • Oct 1, 2012
  • Chinese journal of otorhinolaryngology head and neck surgery
  • Sheng-Zhi Lin + 5 more

To investigate the application and significance of aerodynamic parameters in voice function assessment. The phonatory aerodynamic system (PAS) was used to collect aerodynamic parameters from subjects with normal voice, vocal fold polyp, vocal fold cyst, and vocal fold immobility. Multivariate statistical analysis was used to compare measurements across groups. Phonation threshold flow (PTF), mean flow rate (MFR), maximum phonation time (MPT), and glottal resistance (GR) in one hundred normal subjects were significantly affected by sex (P < 0.05), while phonation threshold pressure (PTP), subglottal pressure (SGP), and vocal efficiency (VE) were not (P > 0.05). PTP, PTF, MFR, SGP, and MPT were significantly different between normal voice and voice disorders (P < 0.01), and there were no significant differences among the three disorders (P > 0.05). Receiver operating characteristic (ROC) analysis found that PTP, PTF, SGP, MFR, MPT, and VE in one hundred thirteen voice dis orders had similar diagnostic utility (P < 0.01), with PTP exhibiting the highest area under the curve. The aerodynamic parameters of the three degrees of voice dysfunction due to vocal cord polyps were compared and found to have no significant differences (P > 0.05). PTP, PTF, MFR, SGP and MPT in forty one patients with vocal polyps were significantly different after surgical resection of vocal cord polyps (P < 0.01). The aerodynamic parameters can objectively and effectively evaluate the variations of vocal function, and have good auxiliary diagnostic value.

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  • 10.1016/j.jvoice.2023.12.018
Geriatric Voice: Distinctive Clinical Profiles of Working Seniors in a Tertiary Laryngology Clinic
  • May 1, 2026
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  • Cite Count Icon 56
  • 10.1089/thy.2012.0060
Voice Quality After Surgical Treatment for Thyroid Cancer
  • Jul 1, 2013
  • Thyroid
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Thyroidectomy is a standard treatment for thyroid cancers. Hoarseness due to the paralysis of the recurrent laryngeal nerve is one of the most common postoperative complications, and has been studied by many investigators. However, voice quality after thyroidectomy in patients in whom recurrent laryngeal nerves were preserved and vocal cord morbidity was endoscopically normal has not been well studied. To understand voice quality after thyroidectomy further, we conducted a time-course analysis of voice quality in patients who had thyroidectomy with normal cord morbidity by various measures. We evaluated voice parameters including the Voice Handicap Index-10 (VHI-10), the vocal efficacy index, the fundamental frequency (F0), the maximum phonation time (MPT), the mean air flow rate (MFR), jitter, shimmer, and the noise-to-harmonics ratio (NHR) before and after total thyroidectomy (TT) or lobectomy (LO) for thyroid cancers in 110 patients in whom the recurrent laryngeal nerves were preserved without apparent injury and normal vocal cord mobility was confirmed by endoscopic examination. Thirteen patients who underwent parotidectomy were enrolled as controls. Immediately after surgery, significant decreases in MPT (p=0.003) and significant increases in jitters, shimmers, and NHR (p=0.0002, 0.02, and 0.03, respectively) were observed in the patients who underwent TT. In comparison with the controls, jitters and NHR were significantly higher in the patients who had a TT (p=0.03, 0.04). MFR was significantly higher in the patients who had an LO than in the controls (p=0.02). As compared with the patients who had an LO, MPT was significantly shorter (p=0.0004) and MFR and NHR were significantly higher (p=0.004, 0.03) in the patients with a TT. In the patients who had a TT, the MPT immediately after the surgery was significantly longer in the patients who had simultaneously neck dissection (ND) in comparison with the patients who did not have ND. However, all these differences gradually decreased and were not significant at one month after surgery. Our results suggest that TT and ND have a distinct impact on voice quality after surgical treatment for thyroid cancer, probably due to slight and transient nerve conduction disorders induced by the manipulation around recurrent laryngeal nerves and/or laryngeal edema induced by the disturbance of venous and lymphatic drainages. However, these changes appear to be temporary, lasting only a few weeks.

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Predictive value of strobovideolaryngoscopy, acoustic and aerodynamic measures in the prognosis of temporally unilateral vocal fold paralysis after thyroidectomy
  • Oct 1, 2022
  • Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • Renhui Chen + 4 more

Objective:To investigate the strobovideolaryngoscopy, acoustic and aerodynamic characteristics of transient unilateral vocal ford paralysis(UVFP) after thyroidectomy. Methods:A retrospective analysis was made of 11 patients with temporary UVFP after thyroidectomy who were treated in Department of Otolaryngology and Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University from January 2013 to March 2021; 8 patients with permanent UVFP after thyroidectomy during the same period were included as a control group. The differences in baseline strobovideolaryngoscopy, acoustic and aerodynamic measures were compared between the two groups. Results:The tones of patients with temporary UVFP after thyroidectomy were all normal, and the proportions of abnormal vocal fords(vocal ford bowing, atrophy, and shortening), ventricular adduction and glottic insufficiency were significantly lower than those of permanent UVFP patients; arytenoid cartilage stability and height mismatch of vocal ford tended to be better than permanent UVFP. The maximal phonation time(MPT) in patients with temporary UVFP was (8.5±4.1) s, which was significantly longer than (3.9±2.1) s in patients with permanent UVFP; fundamental frequency, mean airflow(MeAF) and mean subglottic pressure(SGP) were better in temporary UVFP than those in patients with permanent UVFP, but the difference did not reach statistical significance. Conclusion:None and mild glottic insufficiency, normal tone, ventricular adduction, and vocal ford appearances without vocal fold bowing, atrophy, and shortening, can be served as the predictors for the early recovery of vocal ford movement in temporary UVFP after thyroidectomy. The MPT less than 4 s, and MeAF, and SGP remarkably increased is the predictor of poor prognosis for vocal ford recovery.

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  • Research Article
  • 10.3390/ohbm4020008
Bilateral Vocal Nodules Multidimensional Assessment: Pre- and Post- Speech Language Pathology Intervention
  • Sep 5, 2023
  • Journal of Otorhinolaryngology, Hearing and Balance Medicine
  • Rita Alegria + 3 more

(1) Background: Vocal fold nodules are bilateral lesions that can have an important negative impact on a person’s job performance, social interaction, and quality of life. This study aims to analyze multidimensional voice evaluation outcomes in a group of patients with bilateral vocal fold nodules who underwent voice therapy. (2) Methods: A retrospective analysis was performed in 42 patients on the following voice evaluations, before and after voice therapy: visual-perceptual (video-laryngostroboscopic evaluation), auditory-perceptual voice analysis based on the GRBAS scale, and aerodynamic voice analysis. Data were collected from January 2001 to December 2019. Data analyses were performed with non-parametric tests (Wilcoxon test) using α = 0.05. (3) Results: The patient average age was 33.6.1 ± 10 years (range 19–60), and 95.2% were female. Voice therapy was delivered by an experienced speech-language pathologist once a week, with an average of 9.8 ± 3 appointments (range 8–17). Vocal fold lesions disappeared in 40.4% of the patients after voice therapy, especially in participants receiving early voice therapy (p = 0.035). When comparing pre- and post-therapy audio-perceptual results, all parameters were improved with statistical significance (p &lt; 0.05) except for the asthenic voice scale. Aerodynamic parameters were all improved but without statistical significance (p &gt; 0.05); (4) Conclusions: Early timing to initiate voice therapy after the onset of symptoms or diagnosis seems to be an important factor for the success of voice therapy (absence of vocal fold nodules).

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  • 10.1002/lary.28796
A New iPhone Application for Voice Quality Assessment Based on the GRBAS Scale.
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  • The Laryngoscope
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View Video S1 Laryngoscope, 131:580–582, 2021

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  • 10.1016/j.jvoice.2024.08.005
Temperament and Voice Quality in Patients With Vocal Fold Nodules
  • Sep 1, 2024
  • Journal of Voice
  • Emine Metin + 4 more

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  • 10.3342/kjorl-hns.2014.57.9.610
The Effects of Botulinium Toxin in Vocal Nodules
  • Jan 1, 2014
  • Korean Journal of Otorhinolaryngology-Head and Neck Surgery
  • Cheol Min Ahn

Background and ObjectivesZZVocal nodules are the most common voice disorder due to vocal misuses. Vocal nodules are primarily treated with voice therapy and are rarely removed through laryngomicrosurgery. Although the rate of recovery for individual patients may vary, 60-70% of them are fully treated. Because vocal nodules have many possible causes, 30-40% of patients remain untreated. Also, vocal nodules recurrence after the surgical treatment is sometimes observed. The author claims that incomplete contact between vocal cords during phonation is a major cause of the vocal nodules. Most vocal nodules do occur from incomplete contact between vocal cords during phonation, and various voice therapies are designed to improve habitual misuses of the vocal cords. However, vocal nodules tend to remain unhealed unless patients change their habitual misuses of the vocal cords. The cricothyroid muscle tension is known to hinder the contact between vocal cords. The author injected a restricted amount of botulinium toxin to the cricothyroid muscle to reduce the muscle tension and observed changes in vocal cords’ movement. Subjects and MethodZZIn this study, the author injected botulinium toxin to the cricothyroid muscle of 21 patients. For 2-4 weeks, we observed patients’ responses to the treatment, by measuring changes in subglottal pressure, mean air flow rate, maximum phonation time, jitter, shimmer, noise-to-harmonic ration of patients and subjective evaluation of voice changes. In addition, the author conducted stroboscopy to evaluate the usefulness of the treatment. ResultsZZThe improvement was in the subjective evaluation of voice changes and stroboscopic findings. ConclusionZZThe observation demonstrated a great improvement in vocal nodules after the injection of botulinium toxin into the cricothyroid muscle.

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  • Cite Count Icon 12
  • 10.1007/s00405-022-07418-3
Voice quality after transoral CO2 laser microsurgery (TOLMS): systematic review of literature
  • May 3, 2022
  • European Archives of Oto-Rhino-Laryngology
  • Andrea Colizza + 4 more

PurposeTransoral laser microsurgery (TOLMS) with carbon dioxide is a safe approach for laryngeal carcinoma. In literature there are three main methods for evaluating speech outcomes: acoustic and aerodynamics analysis, perceptual evaluation and patient-reported outcomes (PROs). The aim of this study was to systematically review the literature about the voice quality outcomes of TOLMS according to type of cordectomy.MethodsA systematic literature review was performed and all the results until December 2021 were extrapolated. We evaluated the acoustic and aerodynamics parameters (fundamental frequency, harmonics to noise ratio, jitter, shimmer and maximum phonation time), perceptual data (GRBAS scale) and patient-related outcomes (VHI scale).Results24 studies met the inclusion criteria for a total number of 1207 patients enrolled. The number for each type of cordectomy are: 287 type I (23.78%), 311 type II (25.78%), 328 type III (27.14%), 129 type 4 (10.69%) and 152 type V (12.60%). Patients are grouped according to the type of cordectomy in: limited cordectomy (type I and II) and extended cordectomy (types III–IV–V). The difference between two groups is statistically significative in terms of acoustic analysis, perceptual data and patient-related outcomes (p < 0.05).ConclusionsPatients who underwent type I or II cordectomy have significantly better quality of voice in terms of VHI, perceptual voice quality evaluations and acoustic parameters compared to type III, IV and V cordectomies. The effect of TOLMS on the voice should depend from the extent of the resection and in particular from the scar of the vocal muscle.

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  • 10.1016/j.jvoice.2022.05.016
Effect of Voice Therapy as a Supplement After Reinnervation Surgery for Breathy Dysphonia Due to Unilateral Vocal Fold Paralysis
  • Jun 24, 2022
  • Journal of Voice
  • Narihiro Kodama + 2 more

Effect of Voice Therapy as a Supplement After Reinnervation Surgery for Breathy Dysphonia Due to Unilateral Vocal Fold Paralysis

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  • 10.3950/jibiinkoka.118.1212
The Correlation between the Size of Vocal Polyps, Vocal Nodules and Vocal Dysfunction, before and after Laryngeal Microsurgery
  • Jan 1, 2015
  • Nippon Jibiinkoka Gakkai Kaiho
  • Chikako Kunieda + 9 more

When we operate on a vocal polyp or a vocal nodule with laryngeal microscopy, we always carefully measure their length and width then multiply the length by the width to get the area. We examined whether there is a correlation between the area of these lesions and the acoustic analysis of voice. Before the surgery and one month post-operation, we checked five acoustic parameters, maximum phonation time (MPT), range of voice, mean air flow rate (MFR) and acoustic analyses (jitter% and shimmer%). By doing this, we could arrive at the improvement rate of each of the five acoustic parameters. We examined whether there was a correlation between the lesion area and acoustic parameters before surgery and the improvement rates of these acoustic parameters. Examinations of polyps showed a correlation between the size and range of voice and Jitter% pre-operation, and showed a correlation between the size and improvement rate of range of voice, MFR, Jitter% and Shimmer% post-operation. On the other hand, examination of nodules showed a correlation only between the size and range of voice pre-operation. Next we examined the correlation between the size and these acoustic parameters in the Elite vocal performer (EVP) group and extra EVP group. In the examinations of polyps, the EVP group showed a lower correlation between the size and acoustic parameters than in the extra EVP group. On the other hand, in the examinations of nodules, correlation between the size and acoustic parameters was low in both the EVP and extra EVP group.

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  • Research Article
  • Cite Count Icon 12
  • 10.1590/s1516-18462011005000002
Tempos máximos de fonação e características vocais acústicas de mulheres com nódulos vocais
  • Feb 4, 2011
  • Revista CEFAC
  • Carla Aparecida Cielo + 3 more

OBJETIVO: descrever os tempos máximos de fonação (TMF) e características vocais acústicas de mulheres adultas jovens com nódulos vocais. MÉTODOS: coleta dos TMF das vogais /a/, /i/ e /u/; da relação s/z e medidas acústicas da fonte glótica (Multi Dimensional Voice Program Advanced da Kay PENTAX) de 20 sujeitos do sexo feminino, com faixa etária entre 20 e 40 anos, dez com laudo otorrinolaringológico de nódulos vocais e dez com laudo de laringe normal. RESULTADOS: quanto aos TMF, o grupo sem nódulos (GSN) apresentou 90% dos resultados normais e 10% diminuídos, e o grupo com nódulos (GCN) apresentou 70% dos resultados normais e 30% diminuídos; na relação s/z, todo o GSN apresentou resultados dentro dos padrões da normalidade e o GCN apresentou 70% de resultados normais e 30% aumentados; ambos os grupos apresentaram todas as medidas vocais acústicas dentro da normalidade, com exceção do GSN que apresentou vf0 aumentada. CONCLUSÃO: as mulheres jovens com nódulos vocais apresentaram medidas de TMF e de relação s/z sem diferenças significativas em relação às mesmas medidas de mulheres sem afecção laríngea. As medidas acústicas da fonte glótica foram semelhantes e dentro da normalidade para ambos os grupos, com exceção da medida do cociente de variação de frequência fundamental (vf0) que foi elevada no GSN, sugerindo incoordenação penumofonoarticulatória. As medidas de TMF e da relação s/z, mesmo sem diferenças significativas, pareceram mais sensíveis à presença do predomínio aerodinâmico dos nódulos vocais do que as medidas acústicas.

  • Research Article
  • Cite Count Icon 21
  • 10.1016/j.jvoice.2016.03.017
Voice Therapy Effect on Mutational Falsetto Patients: A Vocal Aerodynamic Study
  • Aug 30, 2016
  • Journal of Voice
  • Fa-Ya Liang + 10 more

Voice Therapy Effect on Mutational Falsetto Patients: A Vocal Aerodynamic Study

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