Abstract
We read with great interest the article by Graff-Radford et al.,1 which showed that patients with high-convexity tight sulci (HCTS) were associated with a lower tau PET standard uptake value ratio than patients without HCTS. In the Geneva normal pressure hydrocephalus (NPH) cohort,2 we tested the hypothesis that patients with HCTS are associated with decreased CSF phosphorylated tau level. Eighty-three consecutive patients with suspicion of NPH (age: 76.5 ± 7.8 years; 32.5% female) who performed an analysis of CSF biomarkers were included. HCTS has been determined following the definition of the Radscale3: HCTS was considered positive when narrow parietal high-convexity sulci (assessed in the transverse plane in the most superior slices and in the coronal plane) = 2 (presence of vertex narrow sulci).
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