Abstract
I read the article by Mollan et al.1 regarding weight loss and intracranial hypertension (IH) with interest. Gastric bypass results in decreased dicarbonyl stress (DS).2 DS-related compounds, such as methylgloxal, are associated with the breakdown of the blood-brain barrier,3 as seen in IH through the glycation of biomolecules and the production of advanced glycation end products (AGEs).3,4 Inhibiting semicarbazide-sensitive amine oxidase, which causes DS, with caffeine may lead to decreased weight gain and AGEs.5
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