Abstract
Reactivity of LiAlH 4 was controlled by using solid-phase reaction conditions. Tertiary amides bound to gel-type polystyrene support were reduced with LiAlH 4 to give tertiary amines with satisfactory purity, whereas the reduction of similar tertiary amides in solution gave secondary amines as main products. Solid-phase synthesis of tertiary amine libraries was achieved by using this method.
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