Abstract
We have examined the reaction of ethyl bromodifluoroacetate ( 1) in the presence of copper powder as a procedure for the synthesis of compounds containing a CF 2 group. The complex formed in the above reaction reacted with vinyl or aryl iodides to give cross-coupling products, with Michael acceptors to give 1,4-addition products and with olefins to give radical addition products. The cross-coupling reaction was applied to the synthesis of 4,4-difluoro-α-tocopherol.
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