Abstract
Reaction of 1,2,3,4-tetrafluorodibenz[b,f][1,4]oxazepin-11(10H)-one with nucleophilic reagents (MeONa in refluxing MeOH; piperidine in DMF at 100‡C) leads to substitution of the fluorine atom para to the CONH group. 6,7,8,9-Tetrafluorodibenz[b,f][1,4]oxazepin-11(10H)-one is inert to these conditions.
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