Abstract
Basic kinetic data, rate constants, activation energies, and entropies of activation were elucidated for the reactions of 22 kinds of 4-NQO derivatives with sodium ethoxide in anhydrous ethanol by spectroscopic-method. Correlations existed between the rate constants and carcinogenicities, and half-wave reduction potentials. Hammett paramaters were applied to the rate constants, and a linear correlation existed in 6-and 7-substituted derivatives. Interactions of 4-nitro group and 3- or 5-position substituents retarded the rate, but for 2- or 8-position, only bulky substituents such as methyl group interacted with the N-oxide group.
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