Abstract
Good aerobic capacity has a major role in health and longevity. Changes in oxidative metabolism underlie also several complex diseases, such as type 2 diabetes. Koch and Britton (Physiol Genomics, 2001) have developed two distinct rat strains by artificial selection: high‐capacity runner (HCR) and low‐capacity runner (LCR) rats. These rat strains differ in their intrinsic aerobic capacity. The aim of the study is to get more information from HCR/LCR rats as models of metabolic diseases and to find out the effects of aerobic training and aging in longevity, metabolism and muscle function. Muscle function was studied in electrically stimulated contracting gastrocnemius muscle using 1H‐magnetic resonance imaging (MRI) and 31P‐MR spectroscopy. The simultaneous force output was measured with an ergometer connected to foot pedal. Our results from 31P‐MR spectroscopy and mechanical measurement show that there was a significant difference between HCR and LCR groups in the isometric force decrease during transcutaneous stimulation, the decrease being greater in LCR rats (P<0,001). The phosphocreatine resynthesis after stimulation was also significantly slower in LCR group (P<0,02). In conclusion, 31P‐MR spectroscopy seems to be a valid non‐invasive method to investigate energy metabolism in this disease model, making also longitudinal studies feasible. Study is supported by the Ministry of Education, Finland
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