Abstract
Novel ratiometric fluorescent cysteine probes based on naphthalene–thiourea–thiadiazole (NTTA) fluorescent organic nanoparticles (FONs) were designed and synthesized. NTTA FONs show good water solubility, high selectivity for sensing and a 74 nm red-shift of fluorescence emission upon binding cysteine in aqueous media are observed. Under optimum condition, linear relationships are found between the relative fluorescence intensity ratio I 430/ I 356 and the logarithmic concentration of cysteine in the range of 0–100 μM with the detection limit was found to be 1.5 × 10 −9 M, while the FL intensity of NTTA FONs to other amino acids is negligible. The possible mechanism is discussed.
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