Abstract
Drug metabolism in Sprague-Dawley and Long-Evans rats, from two different sources (A and B), was studied in vitro and in vivo. Female Long-Evans (A) rats, but not Long-Evans (B) rats, metabolize pNO 2 anisol, aminopyrine, hexobarbital and imipramine in vitro to a lower extent than Sprague-Dawley rats. Marked sex differences in this respect are evident in both strains. In vivo a reduced elimination of aminopyrine from plasma was obtained in Long-Evans rats (A) as compared to animals from the (B) source. Moreover tissue concentration of imipramine, aminopyrine and phenobarbital were higher Long-Evans (A) than in Sprague-Dawley. The disappearance from plasma of amphetamine and zoxazolamine was apparently not different in the two strains.
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