Abstract
A novel bioinformatics pipeline is used to discover PAX2/5/8 direct downstream targets involved in inner ear development.
Highlights
The pax2/5/8 genes belonging to the PAX family of transcription factors are key developmental regulators that are involved in the patterning of various embryonic tissues
Evolutionary double filtering The primary list of PAX2/5/8 putative downstream targets was obtained in silico, by applying an improved version of the evolutionary double filtering algorithm (EDF) algorithm as described in Del Bene et al [29]
This algorithm requires as input the position weight matrix (PWM) representing the binding site of the transcription factor of interest
Summary
The pax2/5/8 genes belonging to the PAX family of transcription factors are key developmental regulators that are involved in the patterning of various embryonic tissues. More their function in inner ear specification has been widely described. The pax genes encode a family of transcription factors that have been conserved through evolution and play different roles in early development. This family is defined by the presence of a highly conserved motif of 128 amino acids, the paired-domain, which does not have any obvious sequence homology with other known protein domains. A systematic discovery of specific PAX2/5/8 direct targets in the otic vesicle has not yet been performed
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