Abstract
The rapid hot-injection (HI) technique was employed to synthesize magnetic nanoparticles with well-defined morphology (octahedrons, cubes, and star-like). It was shown that the proposed synthetic approach could be an alternative for the heat-up and flow hot-injection routes. Instant injection of the precursor to the hot reaction mixture (solvent(s) and additives) at high temperatures promotes fast nucleation and particle directional growth towards specific morphologies. We state that the use of saturated hydrocarbon namely hexadecane (sHD) as a new co-solvent affects the activity coefficient of monomers, forces shape-controllable growth, and allows downsizing of particles. We have shown that the rapid hot-injection route can be extended for other ferrites as well (ZnFe2O4, CoFe2O4, NiFe2O4, and MnFe2O4) which has not been done previously through the HI process before.
Highlights
Reference Fe3O4 magnetic iron oxide nanoparticles (MNPs) were fabricated through repetition of the simple and efficient one-pot synthesis based on the heat-up approach proposed by Kim et al.[23] at 290 C with the heating rate of 20 C minÀ1
Based on the TEM analysis we found that downsizing of the MNPs with saturated hydrocarbon namely hexadecane (sHD) can be achieved to 46 nm while keeping cubic morphology for a maximum of 10 mmol of sHD in the reaction mixture (Fig. 4c)
We have shown that the rapid hot-injection technique can be alternatively used for morphology and particle size controlled MNPs at a relatively short synthesis time (30 min) minimizing the risk of main benzyl ether (BE) solvent decomposition
Summary
The huge interest of many research groups in the development of magnetic iron oxide nanoparticles (MNPs) is a direct consequence of their exceptional, strongly size and morphology dependent magnetic properties as well as acceptable biocompatibility and sufficient biodistribution.[1,2,3] MNPs can be exploited in a variety of biomedical applications both at diagnostic and therapy levels such as in magnetic resonance imaging (MRI),[4,5] localized drug delivery,[6,7,8] tissue regeneration[9] or hyperthermia.[10,11] Several interesting studies devoted to the synthetic issues of MNPs were already published. One can nd a plethora of scienti c articles dedicated to synthetic approaches toward
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