Abstract
Objective To explore the possibility of guiding clinical fast diagnosis and rational use of drugs by rapid detection of plasma digoxin concentration(PDC) with i4000.Methods The plasma samples of 132 patients were collected and digoxin concentration was detected by i4000,and the relationship between PDC and clinical effect was analyzed.Then,the regularities of distribution of digoxin concentration also analyzed according to the age and PDC.The patients whose PDC beyond the effective concentration 0.8 ～ 2.0 μg/L,were treated with adjusted dose respectively according to the circumstance and continuous monitoring of PDC.Results In 132 cases,PDC of 106 patients within the therapeutic dose,accounted for 80.30％,and the total effective rate was 86.36％ after treatment.The effective rates in ＜0.8μg/L group,0.8 ～2.0μg/L group and ＞2.0μg/L group were 10.91％,95.28％and 75.00％,respectively.After dosage adjusted for 1 1 cases with PDC ＜ 0.8μg/L and 4 cases ＞ 2.0μg/L,the PDC returned to the effective concentration.The PDC in over 60 years old group was higher than that in 50 ～ 60 years old group.Poisoning symptoms occurred in 7 cases,and symptoms disappeared through adjustment dosages.Conclusion The PDC detection by Abbott i4000 is rapid and easy to operate,and the result is accurate and reliable. Key words: Digoxin; Drug monitoring; Abbott i4000
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