Abstract
In this paper, we demonstrate the application of Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique to rapid and selective crystallization of a small drug compound. i.e. acetaminophen. Subsequent characterization of the crystals by optical microscopy, powder X-ray diffraction (PXRD) and Raman spectroscopy showed quantitatively selective growth of different crystal forms at various experimental conditions. Acetaminophen crystals were grown predominantly as Form I (99%) on blank glass slides at room temperature. Form II crystals with 39% purity grown on SIFs using microwave energy.
Highlights
The determination of crystal structure of organic and biological molecules affords a better understanding of their behavior, both in-vivo and in-vitro [1, 2]
The Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique is based on the combined use of silver island films (SIFs) and low power microwave heating that results in selective crystallization of molecules of interest through selective nucleation on SIFs and rapid evaporation of the solvent
We have presented the application of the MA-MAEC technique to rapid and selective crystallization of a small drug compound. i.e., acetaminophen
Summary
The determination of crystal structure of organic and biological molecules affords a better understanding of their behavior, both in-vivo and in-vitro [1, 2]. Various crystallization techniques are reported for the rapid growth of higher-quality crystals of organic and biological molecules [3,4,5] In this regard, Garetz et al, employed polarized laser light irradiation to crystallize amino acids in solution [6]. Hamilton et al demonstrated the use of engineered surfaces such as nanoscale cylindrical pores in an effort to control polymorphism [7]. Myerson research group has developed crystallization platforms with selfassembled monolayers (SAMs) of alkane thiols for crystallization of biological and organic molecules using micro-droplet solvent evaporation [8]. Previous work from our lab has demonstrated the use of Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique as a quick and efficient method of growing crystals of amino acids with Trout et al described a detailed investigation of the role of surface chemistry and morphology of porous polymer surfaces on heterogeneous nucleation of aspirin [9].
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