Abstract
Atopic dermatitis is a major contributory factor in chronic hand eczema.’ There is no uniformly successful treatment of either chronic hand eczema or atopic dermatitis.2 The histamine type 2 receptor antagonist, ranitidine, possesses immunomodulating properties, possibly because of its inhibition of histamine activity.3 We have seen alleviation of chronic hand eczema in a few atopic patients treated with ranitidine for gastric ulcer. This observation prompted a placebocontrolled trial to determine whether ranitidine is effective in the treatment of chronic hand eczema in atopic patients.
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