Abstract
Objective To evaluate response to radiotherapy in dogs with oral malignant melanomas. Design Clinical trial. Animals 36 dogs with histologically confirmed oral malignant melanomas. Procedure The prescribed radiation dose was 36 Gy given in 4 fractions of 9 Gy at 7-day intervals. The primary radiation source was a linear accelerator. Results In 25 of 36 dogs, complete remission was achieved, and in 9 dogs, partial remission was achieved. Recurrence of the primary tumor was the cause of euthanasia of 4 dogs. Twenty-one dogs were euthanatized because of metastasis. Clinical Implications Radiotherapy was an effective palliative treatment for the primary tumor in dogs with oral malignant melanomas. However, rapid development of metastatic disease remained a major challenge, (J Am Vet Med Assoc 1996;209:98–102)
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