Abstract
Objective: In the living organisms, deleterious effects produced by ionizing radiations. Human exposure to ionizing radiations increased enormously because of rapid technological advancements. There is a need to protect humans against such effects of ionizing radiation. Protection against the deleterious effects of ionizing radiations by radioprotectors was studied, which may be of great help for human application. Present study was conducted to evaluate the modulating efficacy of prolonged administration of Aloe vera extract against gamma irradiation-induced toxicity in mice.
 Methods: Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/d for 15 consecutive days before radiation exposure (0.5, 3 and 5.5 Gy gamma radiation).
 Results: Mice were autopsied at day ¼, 1, 3, 5, 10 and 20 after irradiation to evaluate the radio modulator effect in terms of the hepatosomatic index.
 Conclusion: Aloe vera extract has a beneficial protective effect against radiation-induced oxidative stress.
Highlights
We all are familiar with the harmful effects of radiations
Mice were autopsied at day 1⁄4, 1, 3, 5, 10 and 20 after irradiation to evaluate the radio modulator effect in terms of the hepatosomatic index
Value of hepatosomatic index in normal mice was considered as 100 percent, which decreased to 96.35 percent in mice treated with Aloe alone as represented in table 1 and fig. 1
Summary
We all are familiar with the harmful effects of radiations. Due to rapid technological advancement, day by day the level of radiation is increasing; there is a need to protect living beings against such harmful effects. Many plant extracts have been reported to contain antioxidants that scavenge free radicals produced due to radiation exposure. It has antioxidants properties because it contains vitamin A (carotene), C, B and vitamin E [5]. Ionizing radiation is one of such environmental factor. The present study was conducted to evaluate the protective effects of Aloe vera against radiation-induced hepatic damage
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