Abstract
Background Various studies are ongoing related to the radioprotective agents. Herbal preparations are currently becoming popular because of their beneficial effects with fewer side effects compared to the synthetic/semi-synthetic medicines, and Nigella sativa oil (NSO) is only one of them. Objective To investigate NSO for its antioxidant effects on the heart tissue of rats exposed to ionizing radiation (IR). Methods Thirty six male albino Wistar rats, divided into four groups, were designated to group I (IR plus NSO group) [...]
Highlights
Radiotherapy is an important treatment method for a wide variety of malignancies
Efforts to reduce the toxicity of irradiation to normal tissues, organs, and cells have led to the investigation of cytoprotective agents.[4]
This study aimed to investigate the effects of Nigella sativa oil (NSO) supplementation on oxidant/antioxidant parameters simultaneously in the heart tissue of rats exposed to ionizing radiation (IR)
Summary
Radiotherapy is an important treatment method for a wide variety of malignancies. Ionizing radiation (IR) is known to generate free radicals in irradiated tissues.[1]. Alterations in Total antioxidant status (TAS) and Total oxidant status (TOS), Oxidative stres index (OSI), Sulhydryl group (SH), Lipid hydroperoxide (LOOH), Paraoxonase (PON) levels, Arylesterase (ARE) and Ceruloplasmin (CER) activities in homogenized heart tissue of rats were measured by biochemical methods. Results: In heart tissue of the rats in the IR alone group (group II) LOOH, TOS and OSI levels were found to be higher, ARE activity and TAS level were found to be lower than all of the other groups (p < 0.01). These results support that IR increases oxidative stress and NSO's protective effect.
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