Abstract
The majority of drugs and other organic compounds that are considered foreign to the body undergoes metabolic changes in vivo. Most drugs are metabolized by a system of enzymes of low substrate specificity requirement which is present mainly in the liver but drug metabolism may also take place in the kidneys and lungs. The various products obtained by the metabolism are identified in terms of concentrations and kinetics. Drug metabolism has been described as a detoxication of potentially harmful substances from the environment. This is not strictly true since the resulting products and metabolites can also be toxic. Drugs can undergo many different types of biochemical reactions, which can be divided into four main types, namely, oxidations, reductions, hydrolysis and synthesis. Radiopharmaceuticals are like any other drugs or compounds liable to chemical transformation after their administration in vivo to humans. For radiopharmaceuticals we are only concerned with the parent compound and its radioactive metabolites [1].
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